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Cat. No.	Product Name	Target	Signaling Pathways
T15781	LP-935509	Serine/threonin kinase; AAK1 (AP2 associated kinase 1)	Cell Cycle/Checkpoint; Metabolism; Neuroscience
	LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂，其 IC50=3.3 nM，Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。
T35856	BMS-986176	AAK1 (AP2 associated kinase 1)	Neuroscience
	BMS-986176 是一种有效的AAK1 抑制剂，IC50为 2.2 nM。BMS-986176在神经退行性疾病中有研究的价值。
T70459	BMT-046091
	BMT-046091 is a potent and selective radioligand which inhibits adaptor-associated kinase 1 (AAK1).
T30543	BMS-911172 BMS911172,BMS 911172
	BMS-911172 是一种AAK1 激酶抑制剂，IC50为 35 nM。
T60828	AAK1-IN-2
	AAK1-IN-2 (compound (S)-31) 可用于神经性疼痛的研究，它是衔接蛋白 2 相关激酶 1 (AAK1)的选择性抑制剂 (IC50 = 5.8 nM)，具有脑渗透性。
T63834	AAK1-IN-3 TFA
	AAK1-IN-3 TFA 是一种能够透过血脑屏障的适配蛋白 2 相关激酶 1 (AAK1) 抑制剂 (IC50: 11 nM)，是一种喹啉类似物。AAK1-IN-3 对神经病理性疼痛表现出研究潜力。
T61499	AAK1-IN-4
	AAK1-IN-4 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), capable of efficiently penetrating the central nervous system and exhibiting oral bioactivity. It has demonstrated a high degree of selectivity with an AAK1 inhibitory concentration (IC50) of 4.6 nM, a Filt dissociation constant (Ki) of 0.9 nM, and a cellular IC50 of 8.6 nM. AAK1-IN-4 holds promise as a valuable tool in the investigation of neuropathic pain [1].
T60829	AAK1-IN-3
	AAK1-IN-3 是一种喹啉类似物，可用于研究神经病理性疼痛。AAK1-IN-3 是衔接蛋白 2 相关激酶 1 (AAK1) 抑制剂，IC50为 11 nM，具有脑渗透性。
T61693	AAK1-IN-5
	AAK1-IN-5 is a potent and specific inhibitor of adaptor protein-2-associated kinase 1 (AAK1), characterized by its ability to penetrate the central nervous system and its oral bioavailability. It displays high selectivity, with an AAK1 inhibitory potency (IC 50) of 1.2 nM, a binding affinity (K i) of 0.05 nM, and an inhibitory potency against cellular AAK1 activity (cell IC 50) of 0.5 nM. AAK1-IN-5 holds promise for investigating neuropathic pain in scientific research [1].